Outbreaks, Epidemics, and Pandemics – What’s the Difference?

Epidemiologists working on an outbreak in the field undergo decontamination procedures. Credit: CDC

Outbreaks, epidemics, and pandemics all involve infectious disease, but there are key differences to consider when epidemiologists classify disease cases.


The occurrence of a disease is classified as an outbreak when it occurs in greater numbers than normally expected. It could occur in a larger area or region, a smaller community, or even a specific location, such as a hospital. It can last from days to years or occur seasonally year-after-year. It is generally thought that all cases of an outbreak are related in some way and in general, are more localized than epidemics.

The U.S. Center for Disease Control and Prevention (CDC) sends investigators to outbreak locations to study suspected and confirmed cases of infectious diseases. In a two-year period, the CDC sent scientists and doctors to investigate more than 750 health threats in the United States. Examples of outbreaks investigated by the CDC include meningococcal disease at universities, food-borne outbreaks, and influenza cases.

Examples of Outbreaks

Infectious Disease Ill/Deaths
Cryptosporidium-1993 in Milwaukee 403,000 ill; 100 deaths
Pertussis-2010 in California 9,477 ill; 10 infant deaths
Salmonella infections linked to peanut butter 4 cases in 4 states; resulted in recall of product
Meningitis-2012-from contaminated steroid medication-nationwide occurrence 500 cases; 36 killed
Cyclosporiasis-2014-in 19 U.S. states from contaminated cilantro 304 cases
E. coli-2014-in California, Idaho, Utah, Michigan, Montana, and Washington from contaminated raw clover 19 cases


An epidemic is also an increase in the number of disease cases expected in an area, but is generally a more widespread situation than an outbreak. Though size of the area or region or numbers of disease are not the only factors when classifying an outbreak or epidemic, an epidemic generally has more disease cases over a larger region than an outbreak. The severe acute respiratory syndrome (SARS) epidemic in 2003 affected over 8,000 people worldwide and took the lives of 774 people.

Major Epidemics

Infectious Disease Sick/Deaths
Yellow Fever-July-August, 1832 in New York City
October in New Orleans
Over 3,000 deaths
4,340 deaths
Polio-1952-United States-nationwide 42,173 cases; 2,720 deaths
Severe Acute Respiratory Syndrome-SARS-2003-worldwide occurrences Over 8,000; 774 deaths


A pandemic is an epidemic that occurs over large areas such as entire countries or continents and affects a large proportion of the population. Pandemics have the potential to spread to multiple countries, especially in today’s ease of global transportation.

In contrast to either outbreaks or epidemics, consider the 2009 H1N1 influenza pandemic. The virus was first detected in the United States in April, 2009 and it spread quickly.

By June 11, 2009, there were so many reported cases worldwide that the World Health Organization declared a global pandemic of influenza was underway. More than 70 countries had reported cases of the H1N1 infection and the pandemic alert was raised to the highest level.

The virus continued to spread through populations and nearly doubled from June to early July. By then, all 50 states in the United States had cases of the infection. The U.S. reported the largest number of cases of any country worldwide with over 1 million cases.

Major Pandemics

Infectious Disease Deaths
The Plague (the “Black Death”)-1347-1351 At least 75 million (other estimates as high as 200 million)
Cholera —1830-1851 Began in India, spread worldwide, killed 150,000 Americans
Still affects 3-5 million people and causes nearly 130,000 deaths per year
Spanish influenza-1918 40-50 million people
Asian influenza-1957 2 million people
Hong Kong influenza-1968 1 million people
HIV/AIDS-present At least 60 million infected; 25 million deaths


Virus that causes SARS
The virus that causes Severe Acute Respiratory Syndrome. Credit: Wikipedia

As you can see, there have been multiple influenza pandemics. There are a few reasons that influenza pandemics may occur more readily than other pathogenic pandemics. An influenza pandemic can occur when the causative virus for the flu mutates and results in a new subtype of the virus. Because it is a new subtype, people have little or no immunity to it. Also, since the virus spreads so easily through sneezing and coughing, many people can be infected quickly and the disease can spread worldwide, especially with the prevalence of air travel in today’s societies.

The World Health Organization (WHO) has written an influenza alert system. The four-category rating scale describes pandemic situations.


Pandemic Phases

  • Interpandemic – the period between pandemics.
  • Alert phase – a period of increased monitoring risk assessment is needed because a new viral subtype has been identified.
  • Pandemic – a period of global spread of a new subtype which is evidenced by epidemiological and clinical data of patient cases.
  • Transition – a period in which global risk decreases along with actions and response activities to the pandemic.